• Filippo Migliorini, Jörg Eschweiler, Christian Goetze, Markus Tingart, and Nicola Maffulli.
• Department of Orthopaedic and Trauma Surgery, RWTH University Hospital Aachen, 52074 Aachen, Germany.
• Br. Med. Bull. 2021 Dec 16; 140 (1): 50-61.

IntroductionChondral defects of the knee are common and their management is challenging.Source Of DataCurrent scientific literature published in PubMed, Google scholar, Embase and Scopus.Areas Of AgreementMembrane-induced autologous chondrocyte implantation (mACI) has been used to manage chondral defects of the knee.Areas Of ControversyHyaluronic acid membrane provides better outcomes than a collagenic membrane for mACI in the knee at midterm follow-up is controversial.Growing PointsTo investigate whether hyaluronic acid membrane may provide comparable clinical outcomes than collagenic membranes for mACI in focal defects of the knee.Areas Timely For Developing ResearchHyaluronic acid membrane yields a lower rate of failures and revision surgeries for mACI in the management of focal articular cartilage defects of the knee compared with collagenic scaffolds at midterm follow-up. No difference was found in patient reported outcome measures (PROMs). Further comparative studies are required to validate these results in a clinical setting.© The Author(s) 2021. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

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