• David J Barillo, Claire R Croutch, Anthony R Barillo, Frances Reid, and Al Singer.
• Disaster Response/Critical Care Consultants LLC, Mt Pleasant, SC, 29465, United States. Electronic address: dbarillo@gmail.com.
• Toxicol. Lett. 2020 Feb 1; 319: 111-118.

IntroductionSilver ion has strong antimicrobial properties and is used in a number of wound dressings. In burn models, silver-nylon dressings produce elevated silver levels in the wound along with minimal systemic effect. We evaluated systemic toxicity in a non-burn wound model to see if a similar pattern of silver ion distribution would occur.MethodsEight deep partial-thickness wounds each were created on the dorsum of 40 Gottingen minipigs using a Er-YAG Laser. Half were treated with a 21-day course of silver-nylon dressings (Silverlon®) and half were treated with moist gauze dressings. Wound, blood, liver and kidney silver levels, along with blood chemistry and hematology data were obtained at appropriate intervals.ResultsAll wounds healed well with healing enhanced by silver-nylon dressings. Silver ion was demonstrable in all wounds treated with silver-nylon at day 21 and after 14 days of no further treatment. Silver ion was not detected in blood, liver or kidney of any animal treated with silver-nylon or control dressings. Liver and kidney function remained normal in all animals.ConclusionA 21-day application of silver-nylon dressings to a non-burn dermal wound produces no systemic or local toxicity in Gottingen minipigs.Copyright © 2019 Elsevier B.V. All rights reserved.

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