• Ivana Miljanović-Špika, Maja Drežnjak Madunić, Zlatko Topolovec, Dajana Kujadin Kenjereš, and Domagoj Vidosavljević.
• 1Department of Obstetrics and Gynecology, Faculty of Medicine, Josip Juraj Strossmayer University of Osijek, Osijek, Croatia; 2Osijek University Hospital Center, Osijek, Croatia; 3Department of Obstetrics and Gynecology, Vukovar General Hospital, Vukovar, Croatia; 4Department of Internal Medicine, Vukovar General Hospital, Vukovar, Croatia.
• Acta Clin Croat. 2021 Mar 1; 60 (1): 25-32.

AbstractThe aim of this retrospective study was to show the effect of clinical, pathologic, cytologic and therapeutic prognostic factors on treatment outcome and survival of patients suffering from vulvar cancer and to determine prognostic significance of each of the individual factors, their mutual significance and impact on survival. The study included patients treated for vulvar cancer at Department of Gynecology and Obstetrics, Osijek University Hospital Centre during the 2000-2011 period. Retrospective analysis included data from patient medical files, along with their pathologic and cytologic findings, and oncologist findings. The study included 59 patients aged 45 to 88 years. Diagnosis was based on pathologic and cytologic status and staging. Univariate analysis showed the lymph node status, adjuvant radiotherapy, chemotherapy and clinical staging of the disease to be statistically significant prognostic factors for overall survival and prognosis of vulvar cancer patients. Multivariate analysis of independent prognostic factors for survival of vulvar cancer patients yielded lymph node status, adjuvant radiotherapy and chemotherapy as positive prognostic factors.

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