• Dragana Jovanović, Dana Grujičić, Mihailo Stjepanović, Spasoje Popević, Milica Kontić, and Violeta Vučinić Mihailović.
• 1Medical Faculty, University of Belgrade, Belgrade, Serbia; 2Department of Pulmonology, Clinical Center of Serbia, Belgrade, Serbia; 3Department of Neurosurgery, Clinical Center of Serbia, Belgrade, Serbia.
• Acta Clin Croat. 2021 Mar 1; 60 (1): 131-135.

AbstractApproximately 5% to 15% of patients with systemic sarcoidosis develop neurological complications. However, the actual prevalence of subclinical disease may be higher. Symptoms are not specific, and may resemble those of other neurological diseases. Hydrocephalus occurs in 6% of patients with neurosarcoidosis. Acute hydrocephalus is extremely rare and when it occurs, it is usually difficult to diagnose, thus leading to possible complications. We present a patient who developed acute hydrocephalus due to neurosarcoidosis, for which he had to be operated on; soon after the operation, cranial infection developed that required definitive drainage system and ventriculoperitoneal shunt had to be implanted. In further complicated clinical course, after four years on corticosteroid therapy (corticosteroid dependent sarcoidosis), he had to be urgently operated on because of significant ventricular catheter adhesions, but several days after the operation he died in coma because of progressive brain edema not responding to treatment. As hydrocephalus due to neurosarcoidosis has high morbidity and mortality, early diagnosis and proper treatment are of utmost importance.

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