• Reproductive toxicology · Dec 2010

    Transplacental genotoxicity of antiepileptic drugs: animal model and pilot study on mother/newborn cohort.

    • Aleksandra Fucic, Ranko Stojković, Snježana Miškov, Davor Zeljezic, Darko Markovic, Romana Gjergja, Jelena Katic, Ana Marija Jazbec, Tomislav Ivicevic Bakulic, and Vida Demarin.
    • Institute for Medical Research and Occupational Health, Zagreb, Croatia. afucic@imi.hr
    • Reprod. Toxicol. 2010 Dec 1; 30 (4): 613-8.

    AbstractAntiepileptic drugs (AED) as transplacental agents are known to have adverse effects on fetal development. Genotoxicity of AEDs is still not fully understood. The aim of present study was to investigate the transplacental genotoxicity of valproate on animal model and in 21 mothers and their newborns receiving AED. In both studies, in vivo micronucleus (MN) assay was used. Pregnant dams were exposed to Na-valproate (100mg/kg) on gestational days 12-14. Dams and pups receiving Na-valproate showed a significantly increased MN frequency (5.17 ± 1.17/1000; 5.20 ± 1.48/1000) compared to the control (1.0 ± 0.58/1000; 1.67 ± 1.03/1000). In mother/newborn study a significant increase of MN frequency was detected in newborns of mothers taking AEDs (3.09 ± 0.49/10,000) compared to the referent newborns (1.56 ± 0.22/10,000). The results of this study suggest that AEDs may act as transplacental genotoxins. Launching the mother/newborn cohorts for genotoxicological monitoring may give a significant new insight in health effects of AEDs.Copyright © 2010 Elsevier Inc. All rights reserved.

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