• Arch. Bronconeumol. · Jun 2014

    Real-time prediction of mediastinal lymph node malignancy by endobronchial ultrasound.

    • Hanaa Shafiek, Federico Fiorentino, Alejandro David Peralta, Enrique Serra, Blanca Esteban, Rocío Martinez, Maria Angels Noguera, Pere Moyano, Ernest Sala, Jaume Sauleda, and Borja G Cosío.
    • Departamento de Medicina Respiratoria, Hospital Universitario Son Espases, Palma de Mallorca, España; Departamento de Enfermedades del Tórax, Facultad de Medicina, Universidad de Alejandría, Alejandría, Egipto.
    • Arch. Bronconeumol. 2014 Jun 1; 50 (6): 228-34.

    ObjectiveTo evaluate the utility of different ultrasonographic (US) features in differentiating benign and malignant lymph node (LN) by endobronchial ultrasound (EBUS) and validate a score for real-time clinical application.Methods208 mediastinal LN acquired from 141 patients were analyzed. Six different US criteria were evaluated (short axis ≥10 mm, shape, margin, echogenicity, and central hilar structure [CHS], and presence of hyperechoic density) by two observers independently. A simplified score was generated where the presence of margin distinction, round shape and short axis ≥10 mm were scored as 1 and heterogeneous echogenicity and absence of CHS were scored as 1.5. The score was evaluated prospectively for real-time clinical application in 65 LN during EBUS procedure in 39 patients undertaken by two experienced operators. These criteria were correlated with the histopathological results and the sensitivity, specificity, positive and negative predictive values (PPV and NPV) were calculated.ResultsBoth heterogenicity and absence of CHS had the highest sensitivity and NPV (≥90%) for predicting LN malignancy with acceptable inter-observer agreement (92% and 87% respectively). On real-time application, the sensitivity and specificity of the score >5 were 78% and 86% respectively; only the absence of CHS, round shape and size of LN were significantly associated with malignant LN.ConclusionsCombination of different US criteria can be useful for prediction of mediastinal LN malignancy and valid for real-time clinical application.Copyright © 2013 SEPAR. Published by Elsevier Espana. All rights reserved.

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