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Ann Fr Anesth Reanim · Jan 1985
Review[Reassessment of the respective risks of anaphylaxis and histamine liberation with anesthetic substances].
- S Boileau, M Hummer-Sigiel, R Moeller, and N Drouet.
- Ann Fr Anesth Reanim. 1985 Jan 1; 4 (2): 195-204.
AbstractA search of the French and English language literature of the last 20 years (1964-1984) yielded 975 cases of immediate anaphylactoid reactions due to anaesthetic drugs given parenterally. The accident mechanism was confirmed in only half the patients, and nearly always at a later date. The immunoallergological tests most often used in the diagnostic process were skin tests and Prausnitz-Küstner tests. Although all drugs could be responsible for an anaphylactic reaction, the greatest number of cases was due to muscle relaxants (51%) and hypnotic drugs (42.3%). The signs most often described were cutaneous, cardiovascular, respiratory and occasionally gastro-intestinal. Whilst hypnotic drugs were responsible for cutaneous signs, muscle relaxants gave cardiovascular signs. A past history of drug allergy was found in 37% of cases, and atopy in 38%; virtually all patients had already had one or more anaesthetics.
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