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Int Clin Psychopharmacol · Apr 1987
Randomized Controlled Trial Comparative Study Clinical Trial Controlled Clinical TrialFluvoxamine and imipramine: results of a long-term controlled trial.
- J D Guelfi, J F Dreyfus, and P Pichot.
- Int Clin Psychopharmacol. 1987 Apr 1; 2 (2): 103-9.
AbstractFollowing a multicentre double-blind controlled trial comparing the effects of fluvoxamine and imipramine in depressed inpatients (M.D.E.) 39 patients continued on longer term treatment with maintenance of double-blind conditions (17 on fluvoxamine, 22 on imipramine). The results regarding the reasons for premature interruption of treatment show a slight advantage in favour of fluvoxamine. There were several significant differences in favour of fluvoxamine at the 20th week. The most common side-effects were hot flushes with imipramine and dizziness with fluvoxamine. Overall, despite the small number of patients, the results show a greater clinical tolerance to fluvoxamine than to imipramine.
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