• Minerva anestesiologica · Apr 2022

    Review

    Opioid use, misuse, and abuse: a narrative review about interventions to reduce opioid consumption and related adverse events in the perioperative setting.

    • Daniel D Kim, Maria F Ramirez, and Juan P Cata.
    • Department of Anesthesiology and Perioperative Medicine, MD Anderson Cancer Center, The University of Texas, Houston, TX, USA.
    • Minerva Anestesiol. 2022 Apr 1; 88 (4): 300-307.

    AbstractOpioids remain the most potent and predictable drug available for perioperative analgesia and moderate-to-severe cancer-related pain. However, their efficacy has been questioned in other clinical settings. Moreover, opioids are associated with a wide variety of dose-dependent adverse events, limiting their use. The indiscriminate prescription of opioids has fueled the so-called "opioid epidemic" in the United States and other developed countries. Thus, there has been a significant effort to develop strategies to curtail their unnecessary prescription. Here, we summarize the history, current trends, and new directions in perioperative opioid prescription in an unbiased manner.

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