• Juan P Cata, Vijaya Gottumukkala, Dilip Thakar, Dinesh Keerty, Rodolfo Gebhardt, and Diane D Liu.
• Department of Anesthesiology and Perioperative Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA. Electronic address: jcata@mdanderson.org.
• J Clin Anesth. 2014 Feb 1; 26 (1): 3173-17.

Study ObjectiveTo determine whether postoperative epidural analgesia is associated with better recurrence-free survival and overall survival after lung cancer surgery.DesignRetrospective study.SettingAcademic hospital.MeasurementsData of patients with stage 1, stage 2, and stage 3 nonsmall cell lung cancer, who underwent tumor resection surgery, were studied. Patient data were grouped into three different postoperative pain management interventions: intravenous patient-controlled analgesia, patient-controlled epidural analgesia, and their combination. Univariate and multicovariate Cox proportional hazards models were applied to assess the effects of covariates of interest on overall survival and recurrence-free survival.Main ResultsThe type of postoperative analgesia used for patients who underwent surgery for nonsmall cell lung cancer did not affect recurrence-free survival or overall survival. However, certain variables, including age ≥ 65 years, male gender, body mass index ≥ 25 kg/m(2), ASA physical status 4, and the need for preoperative blood transfusions, pneumonectomy, and postoperative radiation, were associated with decreased recurrence-free survival and overall survival.ConclusionsThe type of postoperative analgesia used after surgery for nonsmall cell lung cancer is not associated with better 2-year or 5-year recurrence-free survival or overall survival rates.© 2013 Elsevier Inc. All rights reserved.

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