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- Nicole C Beatty, Wayne T Nicholson, Loralie J Langman, Timothy B Curry, and John H Eisenach.
- Department of Anesthesiology, Mayo Clinic, Rochester, MN 55905, USA. Electronic address: beatty.nicole@mayo.edu.
- J Clin Anesth. 2013 Dec 1; 25 (8): 662665662-5.
AbstractSerotonin syndrome is gaining attention in perioperative and chronic pain settings due to the growing prevalence of multimodal therapies that increase serotonin levels and thereby heighten patient risk. A patient's genetic make-up may further increase the risk of serotonin syndrome. A case of serotonin syndrome on emergence after general anesthesia is presented. A subsequent cytochrome P4502D6 genetic test result suggested a potential alteration in metabolism. For this patient, who was taking combination antidepressant medications and receiving common perioperative medicines, additive pharmacodynamic effects converged with a pharmacogenetic predisposition, resulting in serotonin syndrome.© 2013 Elsevier Inc. All rights reserved.
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