• Maryam Zain, Fazli Rabbi Awan, Jackie A Cooper, Ka Wah Li, Jutta Palmen, Jay Acharya, Philip Howard, Shahid M Baig, Robert S Elkeles, Jeffrey W Stephens, Helen Ireland, and Steve E Humphries.
• University College London, Faculty of Population Health Sciences, Institute of Cardiovascular Science, Centre for Cardiovascular Genetics, London, UK,Diabetes and Cardio-metabolic Disorders Laboratory, Human Molecular Genetics and Metabolic Disorders Group, Health Biotechnology Division, National Institute for Biotechnology and Genetic Engineering (NIBGE), Faisalabad, Pakistan, Pakistan Institute of Engineering and Applied Sciences (PIEAS), Islamabad, Pakistan.
• J Coll Physicians Surg Pak. 2014 Sep 1; 24 (9): 615-9.

ObjectiveTo determine the sequence variant of TLL1 gene (rs1503298, T > C) in three British cohorts (PREDICT, UDACS and ED) of patients with type-2 Diabetes mellitus (T2DM) in order to assess its association with coronary heart disease (CHD).Study DesignAnalytical study.Place And Duration Of StudyUCL, London, UK. Participants were genotyped in 2011-2012 for TLL1 SNP. Samples and related information were previously collected in 2001-2003 for PREDICT, and in 2001-2002 for UDACS and ED groups.MethodologyPatients included in PREDICT (n=600), UDACS (n=1020) and ED (n=1240) had Diabetes. TLL1 SNP (rs1503298, T > C) was genotyped using TaqMan technology. Allele frequencies were compared using c2 test, and tested for Hardy-Weinberg equilibrium. The risk of disease was assessed from Odds ratios (OR) with 95% Confidence Intervals (95% CI). Moreover, for the PREDICT cohort, the SNP association was tested with Coronary Artery Calcification (CAC) scores.ResultsNo significant association was found for this SNP with CHD or CAC scores in these cohorts.ConclusionThis SNP could not be confirmed as a risk factor for CHD in T2DM patients. However, the low power of thesmall sample size available is a limitation to the modest effect on risk. Further studies in larger samples would be useful.

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