• Clara E Stoesser, Justin J Boutilier, SunChristopher L FCLFSloanSchool of Management, Massachusetts Institute of Technology, Cambridge, MA, USA; HealthcareSystems Engineering, Massachusetts General Hospital, Boston, MA, USA., Steven C Brooks, Sheldon Cheskes, Katie N Dainty, Michael Feldman, Dennis T Ko, Steve Lin, Laurie J Morrison, Damon C Scales, and ChanTimothy C YTCYDepartmentof Mechanical and Industrial Engineering, University of Toronto, Toronto, ON, Canada; LiKa Shing Knowledge Institute, St. Michael's Hospital, Unity Health Toronto, Toronto, ON, Canada..
• Departmentof Mechanical and Industrial Engineering, University of Toronto, Toronto, ON, Canada.
• Resuscitation. 2021 Dec 1; 169: 31-38.

BackgroundAlthough several Utstein variables are known to independently improve survival, how they moderate the effect of emergency medical service (EMS) response times on survival is unknown.ObjectivesTo quantify how public location, witnessed status, bystander CPR, and bystander AED shock individually and jointly moderate the effect of EMS response time delays on OHCA survival.MethodsThis retrospective cohort study was a secondary analysis of the Resuscitation Outcomes Consortium Epistry-Cardiac Arrest database (December 2005 to June 2015). We included all adult, non-traumatic, non-EMS witnessed, and EMS-treated OHCAs from eleven sites across the US and Canada. We trained a logistic regression model with standard Utstein control variables and interaction terms between EMS response time and the four aforementioned OHCA characteristics.Results102,216 patients were included. Three of the four characteristics - witnessed OHCAs (OR = 0.962), bystander CPR (OR = 0.968) and public location (OR = 0.980) - increased the negative effect of a one-minute delay on the odds of survival. In contrast, a bystander AED shock decreased the negative effect of a one-minute response time delay on the odds of survival (OR = 1.064). The magnitude of the effect of a one-minute delay in EMS response time on the odds of survival ranged from 1.3% to 9.8% (average: 5.3%), depending on the underlying OHCA characteristics.ConclusionsDelays in EMS response time had the largest reduction in survival odds for OHCAs that did not receive a bystander AED shock but were witnessed, occurred in public, and/or received bystander CPR. A bystander AED shock appears to be protective against a delay in EMS response time.Copyright © 2021 Elsevier B.V. All rights reserved.

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