• Christina Byrne, Manan Pareek, KrogagerMaria LukacsMLDepartment of Cardiology, Aalborg University Hospital, Aalborg, Denmark., Kristian B Ringgren, Mads Wissenberg, Fredrik Folke, Freddy Lippert, Gunnar Gislason, Lars Køber, Peter Søgaard, LipGregory Y HGYHLiverpool Centre for Cardiovascular Science, University of Liverpool and Liverpool Heart & Chest Hospital, Liverpool, United Kingdom, and Department of Clinical Medicine, Aalborg University, Aalborg, Denmark., Christian Torp-Pedersen, and Kristian Kragholm.
• Department of Cardiology, Rigshospitalet Copenhagen University Hospital, Copenhagen, Denmark. Electronic address: christina.aagaard@sund.ku.dk.
• Resuscitation. 2021 Dec 1; 169: 53-59.

AimLong-term risks of stroke, atrial fibrillation, or flutter (AF), acute coronary syndrome (ACS), and heart failure (HF) among survivors of out-of-hospital cardiac arrest (OHCA) are unknown. We aimed to examine 5-year risks of these outcomes among 30-day survivors of OHCA.MethodsThirty-day survivors of OHCA without a prior (or within 30 days after cardiac arrest) history of stroke, AF, ACS, or HF and population controls without a prior history of these conditions were identified using Danish nationwide registries. Five-year risks of stroke, AF, ACS, and HF standardized to the distributions of age, sex, and comorbidities among OHCA survivors and controls were obtained using multivariable regression.ResultsOf 4,362 30-day OHCA-survivors, 1,051 were stroke-, AF-, ACS-, and HF-naïve and matched with controls using age, sex, and time of OHCA event. Absolute five-year risks for OHCA survivors vs. controls were for stroke: 6.3% [95% confidence interval (CI) 4.1-8.5] vs. 2.0% [1.6-2.5], AF: 7.9% [5.7-10.2] vs. 2.6% [2.1-3.1], ACS: 5.0% [3.2-6.8] vs. 1.5% [1.1-1.9], and HF: 12.7% [10.1-15.4] vs. 1.2% [0.9-1.6], respectively. Corresponding relative risks were 3.18 [95% CI 1.76-4.61] for stroke, 3.03 [1.93-4.14] for AF, 3.23 [1.69-4.77] for ACS, and 10.40 [6.57-14.13] for HF.ConclusionWhen compared with population controls, OHCA survivors had significantly increased five-year risks of incident stroke, AF, ACS, and HF.Copyright © 2021 The Author(s). Published by Elsevier B.V. All rights reserved.

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