• Gulsum Gonulalan, Ibrahim Guney, Fatih Sackan, and Saadet Acar.
• Department of Endocrinology and Metabolism, School of Medicine, KTO Karatay University, Konya, Turkey.
• J Coll Physicians Surg Pak. 2021 Nov 1; 31 (11): 1291-1295.

ObjectiveTo determine the changes of circulating periostin levels in polycystic ovary syndrome (PCOS) and its relationship with metabolic disorders.Study DesignCross-sectional study.Place And Duration Of StudyKonya Research and Training Hospital, Turkey between September 2018 and April 2020.MethodologyPatients with PCOS were compared with healthy individuals as control. The demographics, laboratory findings, anthropometric measurements, the levels of serum periostin and carotid intima media thickness (CIMT) were evaluated and compared.ResultsThere was no significant difference between patients with PCOS (n = 53) and controls (n = 35), according to demographic and laboratory findings and anthropometric measurements. The CIMT in patients with PCOS and control groups were measured as 0.5 ± 0.06 mm and 0.43 ± 0.1 mm, respectively (p <0.003). The levels of periostin in the patients with PCOS and control groups were found to be 6.43 ± 6.19 ng/mL and 3.61 ± 3.79 ng/mL, respectively (p <0.018). No statistically significant correlations were found according to periostin levels and metabolic variables.ConclusionAlthough there was no significant correlation between the periostin levels and the metabolic variables in patients with PCOS as compared to those without the periostin levels, but CIMT were higher in PCOS group. Key Words: Atherosclerosis, Carotid intima-media thickness, Insulin resistance, Periostin protein, Polycystic ovary syndrome.

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