• Sonia Tejedor Vaquero, Leire de Campos-Mata, José María Ramada, Pilar Díaz, Juan Navarro-Barriuso, Clara Ribas-Llaurado, Rodrigo MeleroNataliaNCentre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Barcelona, Spain., Carlo Carolis, Andrea Cerutti, Ramon Gimeno, and Giuliana Magri.
• Translational Clinical Research Program, Institut Hospital del Mar d'Investigacions Mèdiques (IMIM), Barcelona, Spain.
• Front Immunol. 2021 Jan 1; 12: 737083.

AbstractmRNA-based vaccines effectively induce protective neutralizing antibodies against SARS-CoV-2, the etiological agent of COVID-19. Yet, the kinetics and compositional patterns of vaccine-induced antibody responses to the original strain and emerging variants of concern remain largely unknown. Here we characterized serum antibody classes and subclasses targeting the spike receptor-binding domain of SARS-CoV-2 wild type and α, β, γ and δ variants in a longitudinal cohort of SARS-CoV-2 naïve and COVID-19 recovered individuals receiving the mRNA-1273 vaccine. We found that mRNA-1273 vaccine recipients developed a SARS-CoV-2-specific antibody response with a subclass profile comparable to that induced by natural infection. Importantly, these antibody responses targeted both wild type SARS-CoV-2 as well as its α, β, γ and δ variants. Following primary vaccination, individuals with pre-existing immunity showed higher induction of all antibodies but IgG3 compared to SARS-CoV-2-naïve subjects. Unlike naïve individuals, COVID-19 recovered subjects did not mount a recall antibody response upon the second vaccine dose. In these individuals, secondary immunization resulted in a slight reduction of IgG1 against the receptor-binding domain of β and γ variants. Despite the lack of recall humoral response, vaccinees with pre-existing immunity still showed higher titers of IgG1 and IgA to all variants analyzed compared to fully vaccinated naïve individuals. Our findings indicate that mRNA-1273 vaccine triggered cross-variant antibody responses with distinct profiles in vaccinees with or without pre-existing immunity and suggest that individuals with prior history of SARS-CoV-2 infection may not benefit from the second mRNA vaccine dose with the current standard regimen.Copyright © 2021 Tejedor Vaquero, de Campos-Mata, Ramada, Díaz, Navarro-Barriuso, Ribas-Llaurado, Rodrigo Melero, Carolis, Cerutti, Gimeno and Magri.

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