• Aycan Ozdemirkan, Aysegul Kucuk, Isin Gunes, Mustafa Arslan, Aydin Tuncay, Volkan Sivgin, Saban C Sezen, and Hakan Boyunaga.
• From the Department of Anesthesiology and Reanimation (Ozdemirkan, Arslan, Sivgin), Gazi University Faculty of Medicine, from the Department of Medical Biochemistry (Boyunaga), Ankara Medipol University, Ankara, from the Department of Physiology (Kucuk), Faculty of Medicine, Kütahya Health Science University, Kütahya, from the Department of Anesthesiology and Reanimation (Gunes), from the Department of Cardiovascular Surgery (Tuncay), Faculty of Medicine, Erciyes University, Kayseri, and from the Department of Histology and Embryology (Sezen), Faculty of Medicine, Kırıkkale University, Kırıkkale, Turkey.
• Saudi Med J. 2021 Nov 1; 42 (11): 1247-1251.

ObjectivesTo examine the effects of desflurane and cerium oxide (CO) on lung tissue following ischemia-reperfusion injury (IRI).MethodsExperiments were conducted in Gazi University Animal Laboratory, Ankara, Turkey. Thirty rats were divided into 5 groups: control (C), IRI, IRI-CO, IRI-desflurane (IRID), IRI-CO-desflurane (IRICOD). Cerium oxide was given intraperitoneally. Lower extremity IRI was induced. Desflurane was applied during IRI. Lung histopathological examinations and serum biochemical analyses were performed.ResultsSerum nitric oxide (NO) and malondialdehyde (MDA) levels were higher in group IRI (p=0.006) than in group C (p=0.001). Serum MDA and NO levels were significantly lower in groups IRICO and IRICOD than in group IRI. Significantly greater alveolar wall thickening and neutrophil infiltration were recorded in group IRI than in group C. Co-administration of desflurane and CO significantly decreased alveolar wall thickening and neutrophil infiltration compared to group IRI. Total lung injury scores were significantly lower in groups IRID, IRICO, and IRICOD than in group IRI.ConclusionIntraperitoneal CO with desflurane, reduced oxidative stress and corrected the damage in lung. Cerium oxide given before and desflurane given during IRI have been shown to have protective effects on lung damage in rats.Copyright: © Saudi Medical Journal.

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