• Acta clinica Croatica · Dec 2010

    Case Reports

    DRESS syndrome with mild manifestations as a diagnostic and therapeutic problem: case report.

    • Marinko Artuković, Josipa Kustelega, and Liborija Lugović-Mihić.
    • University Department of Internal Medicine, Sveti Duh University Hospital, Zagreb, Croatia. marinko.artukovic@zg.t-com.hr
    • Acta Clin Croat. 2010 Dec 1; 49 (4): 479-84.

    AbstractThe group of severe cutaneous drug reactions with systemic symptoms includes several syndromes: toxic epidermal necrolysis, Stevens-Johnson syndrome, acute generalized exanthematous pustulosis, and drug reaction with eosinophilia and systemic symptoms (DRESS). These reactions occur several days to six weeks after introducing the incriminating drug. The skin and internal organs (liver, kidneys, lungs, etc.) are usually involved. A great possibility of lethal outcome is a critical characteristic of these syndromes. A patient with pyelonephritis diagnosed during emergency room workup is described. Ciprofloxacin was prescribed and the patient was discharged. After ten days, the patient came back with worsening condition, general inflammatory response, skin changes, liver and kidney damage, and eosinophilia. DRESS syndrome was diagnosed based on clinical and other findings. The diagnosis and treatment of severe drug reactions with cutaneous and systemic symptoms pose a medical challenge.

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