• H Matsushita, T Ishiguro, T Kurabayashi, and M Shibuya.
• Department of Obstetrics & Gynecology, Niigata City General Hospital, Shumoku, Chuo-ku, Niigata, Japan. hirosm@aichi-med-u.ac.jp
• Clin Exp Obstet Gyn. 2012 Jan 1;39(3):414-6.

BackgroundAcute generalized exanthematous pustulosis (AGEP) is an uncommon adverse cutaneous reaction, most commonly associated with drugs.CaseA 38-year-old primigravida whose labor had been induced developed erythema over her chest and abdomen. She was transferred to our department after a failed vacuum extraction, and delivered a mature infant by forceps. On day three postpartum she developed a 40.4 degrees C fever. Although ceftriaxone was administered, her fever persisted (>38 degreesC). On day six of the puerperium, diffuse non-follicular pustules appeared over her neck and trunk, and AGEP was suspected. Two days after ceftriaxone was withdrawn, the eruptions started to resolve without any medical intervention.ConclusionOnce the diagnosis of AGEP has been made, the antibiotics being administered must be discontinued. If continued treatment is required, pharmacologically distinct antibiotics must be used instead to aid the rapid self-limitation of the disease.

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