• Reproductive toxicology · Apr 2013

    Comparative Study

    Evaluation of genotoxicity in leukocytes and testis following intra-vasal contraception with RISUG and its reversal by DMSO and NaHCO₃ in Wistar albino rats.

    • A S Ansari, I Alam, M Hussain, S R Khan, and N K Lohiya.
    • Centre for Advanced Studies, Department of Zoology, University of Rajasthan, Jaipur 302004, India.
    • Reprod. Toxicol. 2013 Apr 1; 36: 53-9.

    AbstractEvaluation of genotoxicity of RISUG® - a vas based contraceptive, was carried out in the present study. Animals were allotted into groups of sham operated control, vas occlusion with RISUG (5-7 μl) for 360 days and reversal by DMSO (250-500 μl) and 5% NaHCO₃ (500 μl). Blood samples and testis were collected at 360 days of vas occlusion and 90 days of vas occlusion reversal for comet analysis. Hydrogen peroxide induced samples were used as positive control. Olive moment, tail length and percentage DNA in tail were recorded with minimum variation in all groups for both leukocytes and testis. When compared with positive control the variation was highly significant for both 20 μM and 50 μM H₂O₂ (p<0.001). It is concluded that vas occlusion with RISUG at the contraceptive dose regimen is not associated with genotoxicity in leukocytes or the testis of pre- and post-reversal rats.Copyright © 2012 Elsevier Inc. All rights reserved.

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