• Luka Komić, Ivan Kruljac, Gorana Mirošević, Petar Gaćina, Hrvoje Ivan Pećina, Vatroslav Čerina, Domagoj Gajski, Kristina Blaslov, Krešimir Rotim, and Milan Vrkljan.
• 1University of Split, School of Medicine, Split, Croatia; 2Mladen Sekso Department of Endocrinology, Diabetes and Metabolic Diseases, Sestre milosrdnice University Hospital Centre, Zagreb, Croatia; 3Department of Internal Medicine, Sestre milosrdnice University Hospital Centre, Zagreb, Croatia; 4University of Zagreb, School of Dental Medicine, Zagreb, Croatia; 5Department of Radiology, Sestre milosrdnice University Hospital Centre, Zagreb, Croatia; 6Department of Neurosurgery, Sestre milosrdnice University Hospital Centre, Zagreb, Croatia; 7University of Applied Health Sciences, Zagreb, Croatia; 8Josip Juraj Strossmayer University of Osijek, Faculty of Medicine, Osijek, Croatia; 9University of Zagreb, School of Medicine, Zagreb, Croatia.
• Acta Clin Croat. 2021 Jun 1; 60 (2): 317-322.

AbstractSpontaneous resolution of nonfunctioning pituitary adenoma after hemorrhagic apoplexy is a rare clinical entity of unknown etiology and is defined as disappearance of a tumor without any specific treatment. Here we present a 54-year-old male patient who presented with acute onset of severe headache, vomiting, photophobia, and sonophobia. He was referred to brain computed tomography, which showed a 16x12x16 mm tumor mass located in the sellar region with signs of hemorrhage. Endocrinologic evaluation was consistent with under-function of pituitary gonadotropic cells. Magnetic resonance imaging (MRI) performed ten days later was consistent with hemorrhagic apoplexy of the pituitary adenoma. The patient's symptoms resolved after conservative treatment with dexamethasone, but he was scheduled for elective pituitary surgery. Preoperative MRI was performed one month after the first one and disclosed normal pituitary gland without any signs of adenoma. Our case is remarkable due to the fact that spontaneous remission of pituitary adenoma occurred within the first month, which is the shortest interval reported to date. Our case highlights the importance of conservative therapy as the first-line treatment for pituitary apoplexy in the absence of neurological impairment, since spontaneous remission may occur in a short time interval.

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