• Biochem. Biophys. Res. Commun. · Feb 2013

    Resveratrol suppresses tumor progression via the regulation of indoleamine 2,3-dioxygenase.

    • Kyung Tae Noh, Seung Hoon Chae, Sung Hak Chun, In Duk Jung, Hyun Kyu Kang, and Yeong-Min Park.
    • Department of Microbiology and Immunology, School of Medicine, Pusan National University, Yangsan, Gyeongsangnam-do 626-870, South Korea.
    • Biochem. Biophys. Res. Commun. 2013 Feb 8; 431 (2): 348-53.

    AbstractThis study showed the potential of resveratrol to inhibit the expression and activity of interferon-γ (IFN-γ)-induced indoleamine 2,3-dioxygenase (IDO) in bone marrow-derived dendritic cells (BMDCs). The mechanism of suppression was associated with the activity of Janus kinase/signal transducers and activators of transcription (JAK/STAT) and protein kinase Cδ (PKCδ). In addition, resveratrol-mediated IDO suppression in IFN-γ-stimulated BMDCs appears to play a pivotal role in anti-tumor activity through the regulation of CD8(+) T cell polarization and cytotoxic T lymphocyte (CTL) activity. Systemic administration of resveratrol suppressed tumor growth in EG7 thymoma-bearing mice in an IDO-dependent manner. Taken together, resveratrol not only regulates immune response through the regulation of IDO in a JAK/STAT1- and PKCδ-dependent manner, but also modulates the IDO-mediated immune tolerance in EG7 thymoma.Copyright © 2012 Elsevier Inc. All rights reserved.

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