• Xiaoqiang Li, Jiao Chen, ChunLin Gu, Kejian Lu, Lai Wei, Tao Hu, Jianqiang Song, Shuanjun Zhang, Ya Chen, Qiang Li, Xuan Yu, Yiri Du, Ke Chen, Yu Mao, Min Li, Huanghui Wu, Yan'na Si, Xuze Li, Longyan Li, Xin He, Hui Yu, Stuart Boggett, Colin Royse, David Canty, and Jin Liu.
• Department of Anesthesiology, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
• J. Cardiothorac. Vasc. Anesth. 2022 Apr 1; 36 (4): 1100-1110.

ObjectiveTo determine whether brief ultrasound-guided treatment of hemodynamic shock and respiratory failure immediately before emergency noncardiac surgery reduced 30-day mortality.DesignParallel, nonblinded, randomized trial with 1:1 allocation to control and intervention groups.SettingTwenty-eight major hospitals within China.ParticipantsSix-hundred sixty patients ≥14 years of age, scheduled for emergency noncardiac surgery with evidence of shock (heart rate >120 beat/min, systolic blood pressure< 90 mmHg or requiring inotrope infusion), or respiratory failure (Pulse Oxygen Saturation <92%, respiratory rate >20 beat/min, or requiring mechanical ventilation).InterventionsA brief (<15 minutes) focused ultrasound of ventricular filling and function, lung, and peritoneal spaces, with predefined treatment recommendation based on the ultrasound was performed before surgery or standard care.Measurements And Main ResultsThe primary outcome was 30-day mortality. Secondary outcomes included changes in medical or surgical diagnosis and management due to ultrasound, intensive care unit, and hospital stay and cost, and Short Form-8 quality-of-life scores. Although there were frequent changes in diagnosis (82%) and management (49%) after the ultrasound, mortality at 30 days was not different between groups (50 [15.7%] v 53 [16.3%]; odds ratio 1.05, 0.69-1.6, p = 0.826). There were no differences in the secondary outcomes of the days spent in the hospital (mean 13.8 days, 95% confidence interval [CI] 12.1-15.6 v 14.4 d, 11.8-17.1, p = 0.718) or intensive care unit (mean 9.3 days, 95% CI 7.7-11.0 v 8.7 d, 7.2-10.2, p = 0.562), hospital cost (USD$14.5K, 12.2-16.7 v 13.7, 11.5-15.9, p = 0.611) or Short Form-8 scores at one year (mean 80.9, 95% CI 78.4-83.3 v 79.7, 76.9-82.5, p = 0.54) between participants allocated to the ultrasound and control groups.ConclusionsIn critically ill patients with hemodynamic shock or respiratory failure, a focused ultrasound-guided management did not reduce 30-day mortality but led to frequent changes in diagnosis and patient management.Copyright © 2021. Published by Elsevier Inc.

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