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J. Pediatr. Hematol. Oncol. · Jan 2003
Case ReportsPolyclonal proliferation of lymphocytes containing the epstein-barr virus genome in a patient dying of myocarditis in chronic active Epstein-Barr virus infection.
- Mami Fujiwara, Hiroyuki Shimozono, Hiroaki Ono, Naoto Fujita, Shinichirou Nishimura, Kazuhiro Ueda, and Mayumi Kaneko.
- Department of Pediatrics, Faculty of Medicine, Hiroshima University Hospital, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8551, Japan. mamisuke@h.do-up.com
- J. Pediatr. Hematol. Oncol. 2003 Jan 1; 25 (1): 85-8.
AbstractAn 11-year-old boy had intermittent fever and hepatosplenomegaly. The diagnosis of chronic active Epstein-Barr virus (EBV) infection was established from an abnormal pattern of anti-EBV antibody; EBV was detected in bone marrow cells. Immunochemotherapy alleviated the patient's symptoms. However, when a subsequent oral prednisolone dose was tapered, heart failure ensued and he died. Autopsy findings demonstrated that myocarditis resulted from infiltrating T lymphocytes with the EBV genome and a benign histologic appearance. A clonality study of T lymphocytes indicated no such evidence of monoclonality. EBV-infected T cells play an important role in the pathogenesis of myocarditis in chronic active EBV infection.
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