• Yuxiang Ma, Yunpeng Yang, Yan Huang, Hongyun Zhao, Xue Hou, Ying Tian, Yuanyuan Zhao, Cong Xue, Wenfeng Fang, Xuan Wu, Zhihuang Hu, Wenhua Liang, Ting Zhou, Tao Qin, and Li Zhang.
• Sun Yat-Sen University Cancer Center, Department of Medical Oncology, Guangzhou, China.
• Lung Cancer. 2014 Jun 1; 84 (3): 301-6.

ObjectivesThis study was designed to assess the disease-related symptom burden and quality of life (QOL) in Chinese chemo-naïve advanced lung cancer patients.Materials And MethodsChemo-naïve patients with stage III/IV lung cancer were enrolled. 43 centers from 16 provinces of China participated in the study. Functional Assessment of Cancer Therapy-Lung (FACT-L) scale and Cloud QOL System were applied in the study.Results376 eligible patients were analyzed. The three most common and severe symptoms were appetite loss (84.3%, scored 2.46), breathing difficulty (79.0%, scored 2.56), and cough (75.5%, scored 2.81). Significant correlation was found between QOL and symptoms. Regression analysis of QOL indicated that almost every symptom item (except shortness of breath) was the negative indicator of QOL. Moreover, pulmonary diseases, pleural metastases and brain metastases had significant negative impact on both symptoms and QOL. Relatively poor performance status affected the QOL only, while cardiovascular diseases merely affected the symptoms. And patients with EGFR mutations had less symptom burden than those with wild-type EGFR.ConclusionQOL evaluation by using the Cloud QOL System was feasible. Appetite loss, breathing difficulty and cough were the three most common and severe symptoms seen in Chinese chemo-naïve advanced lung cancer patients. Almost all symptoms had negative impact on QOL. And some clinical characteristics could predict the symptoms and QOL.Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.

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