• Substance use & misuse · Sep 2010

    Neuromodulation of decision-making in the addictive brain.

    • Shirley Fecteau, Felipe Fregni, Paulo S Boggio, Joan A Camprodon, and Alvaro Pascual-Leone.
    • Berenson-Allen Center for Noninvasive Brain Stimulation, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA. sfecteau@bidmc.harvard.edu
    • Subst Use Misuse. 2010 Sep 1; 45 (11): 1766-86.

    AbstractNoninvasive brain stimulation of the dorsolateral prefrontal cortex with repetitive transcranial magnetic stimulation and transcranial direct current stimulation can modify decision-making behaviors in healthy subjects. The same type of noninvasive brain stimulation can suppress drug craving in substance user patients, who often display impaired decision-making behaviors. We discuss the implications of these studies for the cognitive neurosciences and their translational applications to the treatment of addictions. We propose a neurocognitive model that can account for our findings and suggests a promising therapeutic role of brain stimulation in the treatment of substance abuse and addictive behavior disorders.

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