• Mxolisi Justice Ndlovu, Victor Patrick Bagla, Matlou Phenius Mokgotho, Marema Ephraim Makgatho, and Thabe Moss Matsebatlela.
• Department of Biochemistry, Microbiology and Biotechnology Faculty of Sciences and Agriculture.
• Afr Health Sci. 2021 Jun 1; 21 (2): 663-672.

BackgroundCervical cancer is common in women in less developed regions of the world. The plant biomolecules can be employed for synergistic activity with chemo- and radiotherapy. This combinations might result in reduced toxicity and increased efficacy of the treatment regimen.ObjectivesThe anti-HeLa cells activity of the acetone extracts of S. plumosum, T. cilliata and S. pinnata was assessed using different parameters.MethodsSecondary metabolite detection and antioxidant activity quantification were determined using the DPPH and ferric iron reducing assays. HeLa cell growth inhibition and mechanistics were assessed by employing MTT and Annexin-V flous assays.ResultsObservations revealed the presence of phenolic, flavonoids, tannins steroids and coumarins in all the plants extracts. High amount of total phenolic and flavonoid content were detected in S. plumosum and T. cilliata. S. plumosum extract had the best DPPH scavenging activity and ferric reducing powers.ConclusionObservable concentration dependent cell proliferation inhibition by test materials was exhibited. The leaf extracts from T. cilliata, S. plumosum and S. pinnata contain compounds of various polarities with free-radical, antioxidant and anti-cancerous activities that may play a beneficial role in treatment.© 2021 Ndlovu MJ et al.

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