• Tao Xu, Hui Zhang, Xueliang Qiu, and Yuping Meng.
• First Department of Neurology, The First Hospital of Zibo, Zibo City, Shandong Province, P.R. China.
• Afr Health Sci. 2021 Jun 1; 21 (2): 866-874.

ObjectiveThe potential correlation between the ε2/ε3/ε4 variants of the ApoE (Apolipoprotein E) gene and the odds of mesial temporal lobe epilepsy was investigated.MethodsThe database searching for eligible studies was performed in October 2020. A series of pooling analyses were conducted.ResultsWe enrolled a total of twelve case-control studies for pooling. Within the pooling analysis of ε4, there was an increased risk of mesial temporal lobe epilepsy in cases under the models of carrier ε4 vs. ε3, ε3ε4 vs. ε3ε3, and ε3ε4+ε4ε4 vs. ε3ε3 [P < 0.05, odds ratio (OR) > 1], compared with controls. Moreover, we observed similar positive results in the subgroup analyses of "China" and "Population-based control" under the genetic models of ε4 (P < 0.05, OR > 1). Nevertheless, we did not detect the significant difference between the mesial temporal lobe epilepsy cases and controls in the pooling analyses of ε2 (all P > 0.05).ConclusionThe ε3ε4 genotype of ApoE seems to be linked to the risk of mesial temporal lobe epilepsy for patients in China. More sample sizes are required to confirm the potential role of ApoE isoforms in the susceptibility to diverse types of epilepsy from different origins.© 2021 Xu T et al.

19 keywords...

hide…