• Christian Labadie, Stefan Hetzer, Jessica Schulz, Toralf Mildner, Monique Aubert-Frécon, and Harald E Möller.
• Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany.
• Magn Reson Med. 2013 Jul 1; 70 (1): 16-24.

AbstractA procedure to prevent the formation of image and spectral Nyquist ghosts in echo-planar spectroscopic imaging is introduced. It is based on a novel Cartesian center-out echo-planar spectroscopic imaging trajectory, referred to as EPSICO, and combined with a correction of the gradient-echo phase and time shifts. Processing of homogenous sets of forward and reflected echoes is no longer necessary, resulting in an optimized spectral width. The proposed center-out trajectory passively prevents the formation of Nyquist ghosts by privileging the acquisition of the center k-space line with forward echoes at the beginning of an echo-planar spectroscopic imaging dwell time and by ensuring that all k-space lines and their respective complex conjugates are acquired at equal time intervals. With the proposed procedure, concentrations of N-acetyl aspartate, creatine, choline, glutamate, and myo-inositol were reliably determined in human white matter at 3 T.Copyright © 2012 Wiley Periodicals, Inc.

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