• Arch Med Sci · Jan 2021

    Statins as anti-pyroptotic agents.

    • Masoomeh Khalifeh, Peter E Penson, Maciej Banach, and Amirhossein Sahebkar.
    • Department of Medical Biotechnology and Nanotechnology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
    • Arch Med Sci. 2021 Jan 1; 17 (5): 1414-1417.

    IntroductionPyroptosis is a regulated form of cell death, which is often a consequence of the activation of inflammatory caspases.MethodsAppropriate inflammatory responses and the induction of pyroptosis enhance the clearance of pathogens and increase innate immunity.ResultsHowever, excessive pyroptosis contributes to a hyperinflammatory response and aggravates tissue damage, thereby causing inflammatory diseases. There have been recent reports on the modulation of pyroptosis by statins, which may explain part of the pleiotropic actions of these drugs in inflammatory diseases and cancer.ConclusionsHerein, the extant evidence for the potential value of statins in targeting pyroptosis in various diseases is reviewed.Copyright: © 2021 Termedia & Banach.

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