• Lampis C Stavrinou, Evangelia Liouta, Efstathios J Boviatsis, Athanassios Leonardos, Stergios Gatzonis, Pantelis Stathis, Damianos E Sakas, and Efthimis Angelakis.
• 'Petros S. Kokkalis' Hellenic Center for Neurosurgical Research, Athens, Greece. Electronic address: mplam@hotmail.com.
• Clin Neurol Neurosurg. 2019 Oct 1; 185: 105460.

ObjectiveKnowledge on the effects of DBS on cognitive functions is limited and no data exists on the effects of constant-current DBS (CC-GPi-DBS), which appears to prevail over constant-voltage stimulation. Our aim was to prospectively assess the effect of Constant-Current-GPi-DBS, using an 8-contact lead, on cognition, mood and quality of life.Patients And MethodsTen patients aged 27-49 underwent prospective neuropsychological assessment using dedicated tests. Various cognitive domains (intelligence, executive functions, memory, attention, visuo-spatial perception, verbal intelligence) as well as emotional state and quality of life were examined preoperatively and 1, 6 and 12 months after continuous constant-current DBS.ResultsPatients performed preoperatively below average on information processing speed, phonemic verbal fluency and working memory. At 6-months there was an improvement in phonemic verbal fluency (p < .05), which was retained at 12-months postoperatively (p = .05). Results also showed marginal improvement in the Trail Making-A test (p = .051) and the Stroop colour-word test (p < .05). Despite improvement in Quality of Life (Physical and Mental Component improved by 32.42% and 29.46% respectively), patients showed no discernible change in anxiety and depression status.ConclusionsCC-GPi-DBS for primary dystonia has no discernible negative impact on cognition and mood. If anything, we noted an improvement of certain cognitive functions.Copyright © 2019 Elsevier B.V. All rights reserved.

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