• Michiaki Nagai, Satoshi Hoshide, Joji Ishikawa, Kazuyuki Shimada, and Kazuomi Kario.
• Division of Cardiovascular Medicine, Department of Medicine, Jichi Medical University School of Medicine, Yakushiji, Shimotsuke, Japan.
• J. Hypertens. 2012 Aug 1;30(8):1556-63.

ObjectiveRecently, visit-to-visit blood pressure (BP) variability has been shown to be associated with silent cerebral injury and stroke. However, the relationships between visit-to-visit BP variation and cognitive function are not clear.MethodsThe cognitive function was evaluated using a mini-mental state examination (MMSE) and global deterioration scale (GDS) in 201 elderly patients at high risk of cardiovascular disease (CVD) (79.9 ± 6.4 years old; women 75%). Based on 12 visits (once a month), visit-to-visit BP variability (expressed as the SD and coefficient of variation), maximum BP, minimum BP, and δ (maximum - minimum) BP were measured.ResultsThe MMSE score had significant negative correlations with coefficient of variation and δ in SBP, and δDBP. The GDS score had significant positive correlations with coefficient of variation and δ in SBP, and δDBP. Low MMSE score (<24) had significant positive correlations with coefficient of variation and δ in SBP, and δDBP. High GDS score (>3) had significant positive correlations with coefficient of variation and δ in SBP, and δDBP. In a multiple linear regression analysis adjusted for confounders, coefficient of variation (P < 0.001) and δ (P < 0.001) in SBP had significant negative associations with the MMSE score. The δSBP (P < 0.05) had significant positive association with the GDS score. The coefficient of variation and δ in SBP had significant positive associations with low MMSE score (P < 0.01, P < 0.01, respectively) and high GDS score (P < 0.05, P < 0.001, respectively).ConclusionsIn the high-risk elderly, exaggerated visit-to-visit BP fluctuations were significant indicators for cognitive impairment.

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