• J. Neuroimmunol. · Aug 2015

    Fingolimod does not enhance cerebellar remyelination in the cuprizone model.

    • Maria Nordheim Alme, Agnes E Nystad, Lars Bø, Kjell-Morten Myhr, Christian A Vedeler, Stig Wergeland, and Øivind Torkildsen.
    • Department of Clinical Medicine, University of Bergen, Pb 7804, 5020 Bergen, Norway. Electronic address: maria.alme@uib.no.
    • J. Neuroimmunol. 2015 Aug 15; 285: 180-6.

    AbstractFingolimod (FTY720) is approved for treatment of relapsing-remitting multiple sclerosis. In vitro studies have found that fingolimod stimulates remyelination in cerebellar slices, but in vivo animal studies have not detected any positive effect on cerebral remyelination. The discrepant findings could be a result of different mechanisms underlying cerebral and cerebellar remyelination. The cuprizone model for de- and remyelination was used to evaluate whether fingolimod had an impact on cerebellar remyelination in vivo. We found that fingolimod did not have any effect on cerebellar remyelination, number of mature oligodendrocytes, microglia or astrocytes when fed after cuprizone exposure. Copyright © 2015. Published by Elsevier B.V.

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