• Thomas Yates, Melanie Davies, Emer Brady, David Webb, Trish Gorely, Fiona Bull, Duncan Talbot, Naveed Sattar, and Kamlesh Khunti.
• School of Sport and Exercise Sciences, Loughborough University, Ashby Road, Loughborough, Leicestershire, LE11 3TU, UK. t.e.yates@lboro.ac.uk
• Prev Med. 2008 Oct 1; 47 (4): 417-21.

ObjectiveTo investigate the association of walking activity with inflammatory markers and fasting insulin in a bi-ethnic population screened for type 2 diabetes in Leicester, United Kingdom, between 2005 and 2006.MethodPhysical activity, adipocytokine, high-sensitivity C-reactive protein and fasting insulin measurements were available for 400 individuals screened for type 2 diabetes. Of the 400 participants, 56% were diagnosed with normal glucose control, 36% with prediabetes and 8% with diabetes.ResultsMultivariate statistical analysis showed that those who reported walking for at least 30 min on at least 5 days/week had lower levels of C-reactive protein, interleukin-6, and tumor necrosis factor-alpha compared to those who reported lower walking activity levels, after adjustment for other modes of moderate-to-vigorous intensity physical activity, age, ethnicity, sex, social deprivation and smoking status. Further adjustment for waist circumference attenuated the association of walking with tumor necrosis factor-alpha.ConclusionWalking activity, independent of other forms of physical activity, is associated with lower levels of circulating pro-inflammatory markers.

23 keywords...

hide…