• Yonsei medical journal · Jul 2016

    Meta Analysis

    Aldehyde Dehydrogenase 2 (ALDH2) Polymorphism and the Risk of Alcoholic Liver Cirrhosis among East Asians: A Meta-Analysis.

    • Lei He, Tao Deng, and Hesheng Luo.
    • Department of Gastroenterology, Renmin Hospital of Wuhan University, Wuhan, China.
    • Yonsei Med. J. 2016 Jul 1; 57 (4): 879884879-84.

    PurposeThe aldehyde dehydrogenase 2 (ALDH2) gene has been implicated in the development of alcoholic liver cirrhosis (ALC) in East Asians. However, the results are inconsistent. In this study, a meta-analysis was performed to assess the associations between the ALDH2 polymorphism and the risk of ALC.Materials And MethodsRelevant studies were retrieved by searching PubMed, Web of Science, CNKI, Wanfang and Veipu databases up to January 10, 2015. Pooled odds ratio (OR) and 95% confidence interval (CI) were calculated using either the fixed- or random effects model.ResultsA total of twelve case-control studies included 1003 cases and 2011 controls were included. Overall, the ALDH2 polymorphism was associated with a decreased risk of ALC (*1/*2 vs. *1/*1: OR=0.78, 95% CI: 0.61-0.99). However, in stratification analysis by country, we failed to detect any association among Chinese, Korean or Japanese populations.ConclusionThe pooled evidence suggests that ALDH2 polymorphism may be an important protective factor for ALC in East Asians.

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