• Internal medicine journal · Oct 2015

    Case Reports

    Disseminated Mycobacterium haemophilum skeletal disease in a patient with interferon-gamma deficiency.

    • O Otome, M O'Reilly, and L Lim.
    • Department of Infectious Diseases, Box Hill Hospital, Eastern Health, Melbourne, Victoria, Australia.
    • Intern Med J. 2015 Oct 1; 45 (10): 107310761073-6.

    AbstractDisseminated non-tuberculous mycobacterial (NTM) infection is rare in immunocompetent adults. Anti-interferon-gamma (IFN-γ) autoantibodies have recently been associated with NTM infections, particularly in patients of Asian ethnicity. We describe a case of disseminated Mycobacterium haemophilum skeletal infection due to anti IFN-γ autoantibodies in a 71-year-old Cambodian man. He responded to a combination of anti-mycobacterial antibiotics without requirement for immunomodulator therapy. Testing for acquired IFN-γ deficiency due to IFN-γ autoantibodies should be considered when standard tests for immunodeficiency are negative in patients with unusual or severe opportunistic infections, including NTM.© 2015 Royal Australasian College of Physicians.

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