• Cleve Clin J Med · Nov 2016

    Review

    PCSK9 inhibition: A promise fulfilled?

    • Khendi White, Chaitra Mohan, and Michael Rocco.
    • Fellow, Department of Cardiovascular Medicine, Cleveland Clinic, Cleveland, OH, USA.
    • Cleve Clin J Med. 2016 Nov 1; 83 (11 Suppl 2): S36-S44.

    AbstractThe association of reduced proprotein convertase subtilisin/kexin type 9 (PCSK9) activity with reduced cardiovascular disease (CVD) events--and the need for add-ons to statin therapy to achieve treatment goals--has led to the rapid development and US Food and Drug Administration (FDA) approval of monoclonal antibody therapies to inhibit PCSK9. Now that PCSK9 inhibitors are approved by the FDA for use in certain patients, data from ongoing long-term clinical trials addressing tolerability, safety, and proof of additional reduction in CVD events are eagerly awaited.Copyright © 2016 Cleveland Clinic.

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