• Yassir Mahgoub Bakhiet, Abdullahi Mudi, Tholang Khumalo, Glenda Moonsamy, and Cecil Levy.
• Division of Paediatric Nephrology, Department of Paediatrics and Child Health, Charlotte Maxeke Johannesburg Academic Hospital, Johannesburg, South Africa.
• Afr Health Sci. 2017 Dec 1; 17 (4): 113011361130-1136.

BackgroundDifferent histo-pathological types and treatment response patterns of Idiopathic nephrotic syndrome (INS) have been associated with differences in ethnicity and geographical location.ObjectiveTo provide an update on the steroid response and renal histo-pathological pattern in children treated for INS.MethodMedical records of children with INS treated at the Charlotte Maxeke Johannesburg Academic Hospital were reviewed.ResultsMean age was 5.3 years ± 2.8. The majority (68.1%) of the 163 children were of the black racial group. The highest rate of INS was seen in the 2-6 year age group (71.2%). The black racial group had the highest rate (42/111; 37.8%) of focal segmental glomerulosclerosis (FSGS), and the white race had the highest rate (9/14; 64.3%) of minimal change disease (MCD). Ninety four (57.7%) patients were steroid sensitive (SSNS) while 69 patients (42.3%) were steroid resistant (SRNS). Minimal change disease was the most common histo-pathological type seen in SSNS (60%), while FSGS was the most common observed in patients who had SRNS (65.2%).ConclusionThere appears to be a higher rate of FSGS in all the racial groups, and also a higher rate of MCD in the black race group, when compared to previous reports.

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