• Lung Cancer · Jan 2018

    Characterization of never-smoking and its association with clinical outcomes in Chinese patients with small-cell lung cancer.

    • Xiaozhen Liu, Tao Jiang, Wei Li, Xuefei Li, Chao Zhao, Jinpeng Shi, Sha Zhao, Yijun Jia, Meng Qiao, Limin Zhang, Jiawei Luo, Guanghui Gao, Fei Zhou, Fengying Wu, Xiaoxia Chen, Yayi He, Shengxiang Ren, Chunxia Su, and Caicun Zhou.
    • Department of Medical Oncology, Shanghai Pulmonary Hospital & Thoracic Cancer Institute, Tongji University School of Medicine, Shanghai, 200433, PR China.
    • Lung Cancer. 2018 Jan 1; 115: 109-115.

    ObjectivesSmall-cell lung cancer (SCLC) has been viewed as a smoking-related disease, with only 2% to 5% patients being never-smokers. This study aimed to investigate the clinical characteristics of never-smoking and its association with treatment outcomes in Chinese SCLC patients in real world.MethodsWe performed a retrospective study of 303 patients with SCLC and grouped into smokers and never-smokers. The clinical characteristics and treatment outcomes of two groups were collected and compared.ResultsIn total, 113 patients with limited-stage (LS) SCLC and 190 patients with extensive-stage (ES) SCLC were enrolled. Sixty-nine (22.8%) patients were never-smokers. Both the median progression-free survival (PFS) and overall survival (OS) were significantly longer in never-smokers than in smokers (PFS, 8.37 vs. 7.10 months, P=0.036; OS, 19.73 vs. 14.40 months, P=0.044) in all populations. Multivariate analysis suggested that never-smoking was a significant favorable prognostic factor for PFS (HR=0.753; P=0.047) instead of OS (HR=0.780; P=0.236) in patients with SCLC. The objective response rate (ORR) to first-line therapy were similar between two group (52.6% vs. 59.4%, P=0.315). Moreover, prophylactic cranial irradiation (PCI) resulted in marginally significantly longer PFS than observation in patients with ES-SCLC who obtained objective response after first-line therapy (10.57 vs. 7.73 months, P=0.075).ConclusionThe current study indicated that never-smokers are increasingly prevalent in Chinese patients with SCLC. Never-smokers with SCLC had significantly longer PFS and OS compared with smokers, and smoking was an independent poor prognostic factor for PFS in patients with SCLC.Copyright © 2017 Elsevier B.V. All rights reserved.

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