• Salih Celepli, Bayram Çolak, Pınar Celepli, İrem Bigat, Hatice Gül Batur, Furkan Soysal, Serdar Karakurt, Sema Hücümenoğlu, Kemal Kısmet, and Mustafa Şahin.
• Gülhane Training and Research Hospital, Department of General Surgery - Ankara, Turkey.
• Rev Assoc Med Bras (1992). 2022 Jan 1; 68 (1): 87-93.

ObjectiveThe aim of this study was to evaluate the hepatoprotective effect and mechanism of action of artichoke leaf extract in hepatic ischemia/reperfusion injury.MethodsRats were divided into three groups such as sham, control, and artichoke leaf extract groups. Antioxidant enzyme activities and biochemical parameters were examined from the tissue and serum obtained from the subjects. Histopathological findings were scored semiquantitatively.ResultsStatistically, the antioxidant activity was highest in the artichoke leaf extract group, the difference in biochemical parameters and C-reactive protein was significant compared with the control group, and the histopathological positive effects were found to be significantly higher.ConclusionsAs a result, artichoke leaf extract had a hepatoprotective effect and that this effect was related to the antioxidant and anti-inflammatory effects of artichoke.

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