• Carl Chauvin, Gregory Klar, Wilma M Hopman, da SilvaLeopoldo MunizLMDepartment of Anesthesiology, São Luiz Hospital - ITAIM / Rede D'Or - CMA Anestesia team, São Paulo, SP, Brazil. Electronic address: leopoldo_muniz@hotmail.com., Andrew G Day, Rachel Phelan, Michael McMullen, Kai Chen, Rodrigo Moreira E Lima, and Glenio B Mizubuti.
• Department of Anesthesiology and Perioperative Medicine, Queen's University, 76 Stuart Street, Kingston, Ontario K7L 2V7, Canada. Electronic address: crchauvin@gmail.com.
• J Clin Anesth. 2022 May 1; 77: 110630.

Study ObjectivesTo characterize the accuracy of epidural waveform analysis (EWA) in assessing the functionality of thoracic epidural catheters in the immediate postoperative period (primary objective), and to determine the inter-rater reliability between EWA waveform observers (secondary outcome).DesignSingle center, prospective diagnostic accuracy cohort study.SettingPost-anesthetic care unit of a university teaching hospital.Patients84 adult patients undergoing elective thoracic, gynecologic, vascular, urologic, or general surgery with preoperative placement of a thoracic epidural catheter for perioperative analgesia.InterventionsEWA tracings were video recorded in the immediate postoperative period through the epidural catheter in the post-anesthetic care unit.MeasurementsPostoperative EWA tracings were compared with clinical assessments of the sensory block to ice produced by epidural local anesthetic in the immediate postoperative period. Additionally, intra-class correlation analysis of agreement between 3 independent (and blinded) EWA waveform observers was carried out.ResultsAmong 80 patients with thoracic epidurals who completed the study protocol, 73 demonstrated postoperative functional epidurals with sensory block to ice and 7 demonstrated non-functional epidurals. EWA yielded 65 true positives, 6 true negatives, 8 false negatives, and 1 false positive. Postoperative EWA sensitivity, specificity, positive predictive value and negative predictive value, along with the 95% confidence intervals (CI) were 89% (79-95%), 86% (42-100%), 98% (92-100%), and 43% (18-71%) respectively. Intra-class correlation between waveform assessors was 0.870 (95% CI 0.818-0.910, p < 0.001).ConclusionsEWA is useful in assessing the position of thoracic epidural catheters in the immediate postoperative period, demonstrating high sensitivity and specificity as well as robust inter-rater reliability. For patients in whom sensory block to ice cannot be reliably assessed postoperatively, EWA may provide a useful adjunct for assessing epidural functionality.Copyright © 2021 Elsevier Inc. All rights reserved.

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