• Carmelo Tiberio Currò, Antonio Ciacciarelli, Chiara Vitale, Enrica Serena Vinci, Antonio Toscano, Giuseppe Vita, Giuseppe Trimarchi, Rosalia Silvestri, and Massimo Autunno.
• Department of Clinical and Experimental Medicine, University of Messina, Via Consolare Valeria 1, 98124, Messina, Italy. currocarmelotiberio@gmail.com.
• Neurol. Sci. 2021 Nov 1; 42 (11): 4403-4418.

AimsThe objective of this study was to evaluate the impact of the first Italian COVID-19 lockdown on patients with chronic migraine (CM).Material And MethodsThe study was based on an e-mail survey addressed to CM patients of our headache center. The survey evaluated demographic, life style, sleep, psychological, and migraine features during the COVID-19 lockdown period and the month before. The outcomes were migraine impact on daily life and variation in attack frequency, attack duration, migraine pain intensity, migraine symptomatic drugs use per week, and efficacy.ResultsNinety-two patients completed the survey. During the lockdown period, attack frequency was stable in 40,2%, increased in 33,7%, and reduced in 26,1% of patients; attack duration was stable in 55,4%, increased in 23,9%, and reduced in 20,7%. Migraine pain was stable or reduced in 65,2% and increased in 34,8%; number of symptomatic drugs per week was stable in 50%, reduced in 29,3%, and increased in 20,7%; migraine drug efficacy was stable in 73,9%, reduced in 17,4%, and increased in 8,7%. Patients had a HIT-6 score of 64,63 ± 8,81. Significant associations were found with remote working, smoke, education, discontinuation of the therapy performed within headache center, migraine familiarity, sleep, anxiety, perceived stress, concern about future, and COVID-19.ConclusionDuring the lockdown, approximately half of the patients had a clinical stability, a quarter an improvement, and another quarter a worsening. We identified different migraine-influencing elements; in particular, the remote working could represent an easy way to ameliorate migraineurs' life.© 2021. Fondazione Società Italiana di Neurologia.

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