• Satya PrakashM V SMVSDepartment of Anaesthesiology and CC, JIPMER, Puducherry, India., S Sivasankar, Lenin Babu Elakkumanan, V K Mohan, and Rithu Krishna Kamaladevi.
• Department of Anaesthesiology and CC, JIPMER, Puducherry, India.
• Indian J Pharmacol. 2020 Jul 1; 52 (4): 254-259.

BackgroundThe positive effects of midazolam as a premedication in pediatric patients are well documented. Although there are many studies regarding the route and dosage of administration, literature does not have any evidence on the outcome of medication acceptance based on the person administering the drug.AimThe aim of this study was to compare the medication acceptance and preoperative anxiolysis of intranasal midazolam administered by parents and anesthesiologists.Materials And MethodsThis prospective randomized study was conducted in sixty children belonging to the American Society of Anesthesiologists Class 1 or 2 belonging to either sex, aged between 1 and 9 years, undergoing elective surgeries. Group P received intranasal midazolam administered by parents, whereas Group D received intranasal midazolam administered by doctors. Various scores were assessed.ResultsChildren were more sedated in Group P. Clinically, medication acceptance was better in Group P when compared with Group D, but a statistically significant difference in medication acceptance was seen only in patients who are >4 years of age. Parental separation, Ramsay Sedation Score, and mask acceptance were better in Group P than in Group D.ConclusionIntranasal midazolam when given by parents produces better preoperative anxiolysis and easier parental separation as compared with administration by a medical staff.

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