• Tuncay Dagel, Selim Misirlioglu, Serhan Tanju, Baris Afsar, Fatih Selcukbiricik, Suat Erus, Dogan Vatansever, Emre Balik, Cagatay Taskiran, Sukru Dilege, Nil Molinas Mandel, Dursun Bugra, Tunc Yalti, and Mehmet Kanbay.
• Department of Medicine, Division of Nephrology, Koc University School of Medicine, Istanbul, Turkey.
• J Buon. 2018 Sep 1; 23 (5): 1528-1533.

PurposeCytoreductive surgery combined with hyperthermic intraperitoneal chemotherapy (HIPEC) or hyperthermic intrapleural chemotherapy (HIC) has been established as the new treatment modality for selected patients with peritoneal and pleural malignancies. The purpose of the study was to compare the development of acute kidney injury (AKI) in patients who received intravenous cisplatin alone, HIPEC and underwent surgery.MethodsThis retrospective study included 104 patients who underwent different therapeutic procedures including systemic cisplatin, surgery and HIPEC or HIC using cisplatin for the treatment of peritoneal carcinomatosis from a variety of primary tumors at Koc University Hospital and American Hospital between January 2015 to December 2017.ResultsAKI developed in 18 (17.3%) patients. Baseline creatinine was significantly increased in 3 groups after therapies. The development of AKI was highest in patients treated with HIPEC compared to patients treated with intravenous cisplatin and patients who underwent surgery. AKI developed 31.2% in the HIPEC group (10 of 32 patients), 11.7% in the surgery group (4 of 34 patients) and 10.5% in intravenous cisplatin group (4 of 38 patients), respectively (p 0.04).ConclusionHIPEC may not be so safe with regard to kidney function. Every attempt should be taken to decrease kidney damage during this procedure.

18 keywords...

hide…