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- C R Harris, J Gualtieri, and G Stark.
- Emergency Medicine Department, Ramsey Medical Center, St. Paul, MN 55101-2595, USA. harri037@maroon.tc.umn.edu
- J. Toxicol. Clin. Toxicol. 1997 Jan 1;35(3):321-4.
BackgroundBupropion is a unique monocyclic antidepressant that has been known to cause seizures in high therapeutic doses and in acute overdoses. Death due to ingestion, however, is a rare occurrence.Case ReportWe report a case of a 26-year-old man who ingested 23 g bupropion, developed seizures and hypoxia, and presented in cardiac arrest. The patient was resuscitated in the emergency department, but died 4 d after supportive intensive care.ConclusionsBupropion overdose may lead to recurrent seizures, hypoxia and death. Aggressive management of severe bupropion overdose is recommended.
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