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- Shan Li, Ting Liu, Kejing Li, Xinyi Bai, Kewang Xi, Xiaojing Chai, Leyuan Mi, and Juan Li.
- The First School of Clinical Medicine, Lanzhou University, Gansu, China.
- Transl Res. 2022 May 1; 243: 78-88.
AbstractSpectrin, as one of the major components of a plasma membrane-associated cytoskeleton, is a cytoskeletal protein composed of the modular structure of α and β subunits. The spectrin-based skeleton is essential for preserving the integrity and mechanical characteristics of the cell membrane. Moreover, spectrin regulates a variety of cell processes including cell apoptosis, cell adhesion, cell spreading, and cell cycle. Dysfunction of spectrins is implicated in various human diseases including hemolytic anemia, neurodegenerative diseases, ataxia, heart diseases, and cancers. Here, we briefly discuss spectrins function as well as the clinical manifestations and currently known molecular mechanisms of human diseases related to spectrins, highlighting that strategies for targeting regulation of spectrins function may provide new avenues for therapeutic intervention for these diseases.Copyright © 2021 Elsevier Inc. All rights reserved.
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