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- Anna Papa, Dimitra Karabaxoglou, and Athina Kansouzidou.
- Department of Microbiology, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece. annap@med.auth.gr
- J. Med. Virol. 2011 Oct 1; 83 (10): 1861-5.
AbstractCross-reactions in serology are common among flaviviruses. During the outbreak of West Nile virus (WNV) infections in Greece in 2010, WNV IgM-positive serum and cerebrospinal fluid samples were tested for the presence of IgM and IgG antibodies against Dengue virus (DENV) and tick-borne encephalitis virus. Higher cross-reactivity was observed in IgM antibodies between WNV and DENV; however, the index of the WNV antibodies was in all cases higher than that of the DENV antibodies. There is a need for caution when evaluating serologic results of flaviviral infections, while efforts have to be focused on the development of diagnostic assays with increased specificity.Copyright © 2011 Wiley-Liss, Inc.
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