• Childs Nerv Syst · Feb 2004

    Case Reports

    Split cord malformation and situs inversus totalis: case report and review of the literature.

    • R Shane Tubbs, John C Wellons, and W Jerry Oakes.
    • Department of Cell Biology, University of Alabama at Birmingham, and Pediatric Neurosurgey, Children's Hospital, Birmingham, AL 35233, USA. richard.tubbs@ccc.uab.edu
    • Childs Nerv Syst. 2004 Feb 1; 20 (2): 131-4.

    IntroductionSitus inversus is a rare condition of visceral transposition in which the spinal axis is rarely affected.Case ReportThe authors report a patient with situs inversus totalis and type II split cord malformation. This patient had no complaints and presented with scoliosis.ConclusionsRecent compelling evidence from animal models and human case reports has led to hypotheses that defects of the midline and laterality defects (e.g., situs inversus) are etiologically related. Confirmation from additional case reports of situs inversus and split cord malformation could prove useful in determining a genetic locus for split cord malformations or implicating various chemical agents that are known to produce situs inversus as potential causative factors in the production of split cord malformations.

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