• Zhangxuan Hu, Xiaodong Ma, Trong-Kha Truong, Allen W Song, and Hua Guo.
• Center for Biomedical Imaging Research, Department of Biomedical Engineering, Tsinghua University, Beijing, China.
• Magn Reson Med. 2017 Jul 1; 78 (1): 172-181.

PurposeEither SENSE+CG or POCS-ICE methods can be used to correct for motion-induced phase errors in navigator-free multishot diffusion imaging. SENSE+CG has the advantage of a fast convergence, however, occasionally the convergence can be unstable, thus degrading the image quality. POCS-ICE has a stable convergence and can be used with a high number of shots, but its convergence is slow, which limits its practical usage. The study here proposes an improved method based on both SENSE+CG and POCS-ICE, called Phase-updated Regularized SENSE (PR-SENSE), for navigator-free multishot diffusion imaging.Theory And MethodsIn PR-SENSE, a total variation regularization method is used to solve the SENSE inverse problem instead of the conjugate gradient method used in SENSE+CG. This method is implemented by using a lagged diffusivity fixed point iteration algorithm. Additionally, the phase is updated during the iteration process to improve the image accuracy.ResultsSimulations and in vivo experiments demonstrated that PR-SENSE can successfully correct for the motion-induced phase errors in multi-shot DWI. It integrates the advantages of SENSE+CG and POCS-ICE, resulting in a fast and stable convergence with improved image quality.ConclusionGiven its advantages, PR-SENSE is a significant improvement over other methods for navigator-free high-resolution DWI. Magn Reson Med 78:172-181, 2017. © 2016 International Society for Magnetic Resonance in Medicine.© 2016 International Society for Magnetic Resonance in Medicine.

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