• Anticancer research · Jul 2002

    Immunohistochemical detection of eosinophilic infiltration in pulmonary adenocarcinoma.

    • Iwao Takanami, Ken Takeuchi, and Masayoshi Gika.
    • Department of Surgery, Teikyo University School of Medicine, Tokyo, Japan. takanami@med.teikyo-u.ac.jp
    • Anticancer Res. 2002 Jul 1; 22 (4): 2391-6.

    ObjectivesTumor-associated eosinophils play an important role in the biological behavior of cancer. We have detected eosinophilic infiltration immunohistochemically in tissue specimens from patients with pulmonary adenocarcinoma and assessed its association with the prognosis.Materials And MethodsUtilizing the monoclonal antibody for EG2 thought to be a specific marker for eosinophils, the authors quantified eosinophil infiltration immunohistochemically in patients with pulmonary adenocarcinoma to investigate the relationship between EG2- positive cell counts and the prognosis.ResultsA significant difference in the rate of patient survival was detected between patients whose tumors had high EG2-positive cells and patients whose tumors had low EG2-positive cells overall (p=0.0086). Multivariate analysis also showed that eosinophils were significantly related to survival (p=0.044).ConclusionThese data indicate that eosinophilic counts utilizing the monoclonal antibody EG2 serve as a useful independent prognostic marker in pulmonary adenocarcinoma.

      Pubmed     Copy Citation     Plaintext  

      Add institutional full text...

    Notes

     
    Knowledge, pearl, summary or comment to share?
    300 characters remaining
    help        
    You can also include formatting, links, images and footnotes in your notes
    • Simple formatting can be added to notes, such as *italics*, _underline_ or **bold**.
    • Superscript can be denoted by <sup>text</sup> and subscript <sub>text</sub>.
    • Numbered or bulleted lists can be created using either numbered lines 1. 2. 3., hyphens - or asterisks *.
    • Links can be included with: [my link to pubmed](http://pubmed.com)
    • Images can be included with: ![alt text](https://bestmedicaljournal.com/study_graph.jpg "Image Title Text")
    • For footnotes use [^1](This is a footnote.) inline.
    • Or use an inline reference [^1] to refer to a longer footnote elseweher in the document [^1]: This is a long footnote..

    hide…